Multi-omics experiments at bulk or single-cell resolution facilitate the discovery of hypothesis-
generating biomarkers for predicting response to therapy, as well as aid in uncovering …

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …

DNA methylation, a reversible post-replication modification, defines gene expression and
function in different physiologic processes. Hypomethylation is quite common among global …

Background Methylation modification patterns play a crucial role in human cancer
progression, especially in gastrointestinal cancers. We aimed to use methylation regulators …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Rationale Cancer of unknown primary (CUP) is a group of rare malignancies with poor
prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different …

Background Increasing evidence suggests that DXS253E is critical for cancer development
and progression, but the function and potential mechanism of DXS253E in colorectal cancer …

Spatial biology experiments integrate the molecular and histological landscape of tissues to
provide a previously inaccessible view of tissue biology, unlocking the architecture of …

Background Human cytomegalovirus (HCMV) is a herpesvirus that can infect various cell
types and modulate host gene expression and immune response. It has been associated …

DNA 甲基化是一种重要的表观遗传修饰, 在动植物生长发育, 疾病发生, 基因表达调控等方面
发挥着关键作用. 临床上, DNA 甲基化肿瘤标志物可以作为肿瘤的诊断, 预后和治疗的生物标志 …