Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

J Fangusaro, O Witt, PH Driever, AK Bag… - The lancet …, 2020 - thelancet.com
Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS
tumours in children. In general, paediatric low-grade gliomas show clinical and biological …

Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation

T Milde, J Fangusaro, MJ Fisher, C Hawkins… - Neuro …, 2023 - academic.oup.com
Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in young children.
While they are typically associated with good overall survival, children with these central …

Considering functional outcomes as efficacy endpoints in pediatric low-grade glioma clinical trials: an FDA educational symposium

J Fangusaro, RA Avery, MJ Fisher, RJ Packer… - Clinical Cancer …, 2024 - AACR
Abstract In October 2022, the FDA Oncology Center of Excellence hosted an educational
symposium entitled,“Considering Functional Outcomes as Efficacy Endpoints in Pediatric …

Neurobehavioral impairment in pediatric brain tumor survivors: a meta-analysis

Y Wang, APY Liu, TMC Lee, WHS Wong, DYT Fong… - Cancers, 2022 - mdpi.com
Simple Summary Through synthesizing studies regarding neurobehavioral impairment of
pediatric brain tumor survivors (PBTS) in the past decade, this meta-analysis found that …

Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors

EJ Verwaaijen, CE Catsman-Berrevoets… - Neuro-Oncology …, 2021 - academic.oup.com
Background Pediatric brain tumor survivors (PBTS) experience disease-and treatment-
related sequelae. We aimed to investigate the occurrence of participation limitations …

Long-term quality of survival after pediatric low-grade glioma

JM de Bont, AYN Schouten-van Meeteren - Child's Nervous System, 2024 - Springer
Background Low-grade glioma is the most common brain tumor in children with different
modes of treatment and a high overall survival. Low-grade glioma is considered a chronic …

Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the …

S Mueller, J Fangusaro, AO Thomas… - Neuro …, 2024 - academic.oup.com
Within the last few decades, we have witnessed tremendous advancements in the study of
pediatric low-grade gliomas (pLGG), leading to a much-improved understanding of their …

Response assessment in pediatric neurooncology (RAPNO) criteria revisited: a practical navigation guide for neuroradiologists

AF Geraldo, F Maldonado, M Severino, K Mankad… - Neuroradiology, 2024 - Springer
Abstract The Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group
is an international, collaborative network of experts dedicated to pediatric central nervous …

Development of a multi-factorial prognostic model to optimise treatment decision making and outcomes in paediatric low-grade glioma: a mixed methods study

K Green - 2024 - discovery.ucl.ac.uk
Background: PLGG is a histologically benign and generally survivable CNS tumour of
childhood. Varying morbidities from heterogeneous patient, tumour and treatment factors …

Heterogeneity of ASL perfusion MRI in low-grade paediatric glioma as imaging biomarker to assess treatment effect

L Alic, SC Willekens, HJMM Mutsaerts, J Petr… - archive.ismrm.org
ASL-MRI is reported as an option to assess potentially heterogeneous physiological
processes important for tumour treatment. Therefore, we explored the heterogeneity in …