Endothelial cells control the passage of plasma constituents and circulating cells from blood
to the underlying tissues. This specialized function is lost or impaired in several pathological …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …

Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …

G protein-coupled receptors (GPCRs) play important roles in inflammation. Inflammatory
cells such as polymorphonuclear leukocytes (PMN), monocytes and macrophages express …

Src-family tyrosine kinases are regulatory proteins that play a pivotal role in the
disorganization of cadherin-dependent cell–cell contacts. We previously showed that Src …

Classic signaling by the proinflammatory cytokine interleukin 6 (IL-6) involves its binding to
target cells that express the membrane-bound IL-6 receptor α. However, an alternate …

Semaphorin 3A (Sema3A), a known inhibitor of axonal sprouting, also alters vascular
patterning. Here we show that Sema3A selectively interferes with VEGF-but not bFGF …

Diabetic macular oedema (DMO) is an important cause of vision loss in patients with
diabetes mellitus. The underlying mechanisms of DMO, on both macrocellular and …