Targeting Phenotypically Tolerant Mycobacterium tuberculosis
Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …
was a revolution in medicine as physicians went to war with microbes. The second was a …
Recent Advances in Radical C− H Bond Functionalization of Imidazoheterocycles
Direct C− H bond functionalization through radical pathway has emerged as a powerful and
ideal strategy for the synthesis of organic compounds. This review provides an overview of …
ideal strategy for the synthesis of organic compounds. This review provides an overview of …
Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions
The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …
adapted to inhabit a wide range of intracellular and extracellular environments …
Synthesis of new thiazolyl-pyrazolyl-1, 2, 3-triazole derivatives as potential antimicrobial agents
A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
A review on biological and medicinal significance of thiazoles
PM Jadhav, S Kantevari, AB Tekale… - … , Sulfur, and Silicon …, 2021 - Taylor & Francis
Thiazole, a five-membered heterocyclic compound constitutes the skeleton of various
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
Thiazolyl-pyrazole derivatives as potential antimycobacterial agents
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
[HTML][HTML] Antilymphoma activities of benzo bisthiazole derivative by molecular docking, impact of solvation, quantum chemical study, and spectroscopic (FT-IR, UV …
Lymphoma, a type of cancer that affects the lymphatic system—an essential element of the
body's immune defense—has captured increased interest from modern researchers. This …
body's immune defense—has captured increased interest from modern researchers. This …
The relevance of persisters in tuberculosis drug discovery
S Mandal, S Njikan, A Kumar, JV Early… - …, 2019 - microbiologyresearch.org
Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during
exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute …
exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute …
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria
CB Scarim, DH Jornada, MGM Machado… - European journal of …, 2019 - Elsevier
Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …
as primary pharmacophores) in many compounds that are useful to treat several diseases …
Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds
This review highlights the recent synthetic developments of benzothiazole based anti-
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …