Interleukin-1 as innate mediator of T cell immunity
B Van Den Eeckhout, J Tavernier, S Gerlo - Frontiers in immunology, 2021 - frontiersin.org
The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …
The IL-1 family: regulators of immunity
JE Sims, DE Smith - Nature Reviews Immunology, 2010 - nature.com
Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …
shape the adaptive immune response. Among the most potent molecules of the innate …
Genetic variation in Toll-like receptors and disease susceptibility
Toll-like receptors (TLRs) are key initiators of the innate immune response and promote
adaptive immunity. Much has been learned about the role of TLRs in human immunity from …
adaptive immunity. Much has been learned about the role of TLRs in human immunity from …
The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling
S Flannery, AG Bowie - Biochemical pharmacology, 2010 - Elsevier
The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like
receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs are pattern recognition …
receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs are pattern recognition …
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases
S Lavazais, M Jargosch, S Dupont… - Science translational …, 2023 - science.org
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but
also drives adaptive responses. Therefore, modulators of innate immune responses are …
also drives adaptive responses. Therefore, modulators of innate immune responses are …
T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
Abstract Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector
function of IL-17–producing helper T (TH17) cells during autoimmune responses, including …
function of IL-17–producing helper T (TH17) cells during autoimmune responses, including …
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent …
KL Lee, CM Ambler, DR Anderson… - Journal of medicinal …, 2017 - ACS Publications
Through fragment-based drug design focused on engaging the active site of IRAK4 and
leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit …
leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit …
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
Summary Interleukin-1 (IL-1)-mediated signaling in T cells is essential for T helper 17 (Th17)
cell differentiation. We showed here that SIGIRR, a negative regulator of IL-1 receptor and …
cell differentiation. We showed here that SIGIRR, a negative regulator of IL-1 receptor and …
IRAK family in inflammatory autoimmune diseases
LC Su, WD Xu, AF Huang - Autoimmunity reviews, 2020 - Elsevier
Innate immune signaling plays an important role in inflammation, and dysregulation of
signaling components within this pathway has been focused as a critical mediator in …
signaling components within this pathway has been focused as a critical mediator in …
Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells
Background Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease,
for which there are still no diagnostic/prognostic test and therapy. Specific molecular …
for which there are still no diagnostic/prognostic test and therapy. Specific molecular …