With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts
have been made to understand the detailed mechanism of bladder cancer tumorigenesis …

Background NCAPD3 is one of the three non-SMC subunits of condensin II complex, which
plays an important role in the chromosome condensation and segregation during mitosis …

Homologous recombination (HR) repair of DNA double-strand breaks (DSBs) is critical for
maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis …

Triple‐negative breast cancer (TNBC) has higher molecular heterogeneity and metastatic
potential and the poorest prognosis. Because of limited therapeutics against TNBC …

E3 ubiquitin ligase RNF126 (ring finger protein 126) is highly expressed in various cancers
and strongly associated with tumorigenesis. However, its specific function in bladder cancer …

Therapy resistance is a major hurdle to the treatment of human malignant tumors. Both DNA
damage repair and stem-like properties contribute to chemoresistance and radioresistance …

Background Infection with the hepatitis B virus (HBV) is closely associated with the
development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor …

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there is
an unmet need for novel treatment strategies. Here, we characterize the growth arrest and …

Repair of damaged DNA is critical for maintenance of genetic information. In eukaryotes,
DNA double-strand breaks (DSBs) are recognized by the Ku70-Ku80 heterodimer, which …

There is currently a lack of precise predictive biomarkers for patient selection in clinical trials
of inhibitors targeting replication stress (RS) response proteins ATR and CHK1. The …