4,4-Difluoroproline as a Unique 19F NMR Probe of Proline Conformation

HK Ganguly, BA Ludwig, CM Tressler, MR Bhatt… - Biochemistry, 2024 - ACS Publications
Despite the importance of proline conformational equilibria (trans versus cis amide and exo
versus endo ring pucker) on protein structure and function, there is a lack of convenient …

Helical twists and β‐turns in structures at serine–proline sequences: Stabilization of cis‐proline and type VI β‐turns via C–H/O interactions

HC Oven, GPA Yap, NJ Zondlo - Proteins: Structure, Function …, 2024 - Wiley Online Library
Structures at serine‐proline sites in proteins were analyzed using a combination of peptide
synthesis with structural methods and bioinformatics analysis of the PDB. Dipeptides were …

LOCAL ORGANIZATION AT SERINE-PROLINE AND PHOSPHOSERINE-PROLINE SEQUENCES: STABILIZATION OF THE cis-AMIDE CONFORMATION VIA C–H/O …

H Oven - 2024 - udspace.udel.edu
Serine-Proline sequences are abundant in the human proteome, particularly in intrinsically
disordered proteins. Ser-Pro motifs are also highly overrepresented as phosphorylation …