Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

The prospect of transplanting cells and tissues without the risk of immune rejection or the
need for powerful immunosuppressive drugs is the 'holy grail'of transplantation medicine …

Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a
recipient's immune system would abolish the requirement for immunosuppressive drugs or …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

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Natural killer (NK) cells are potent immune effector cells that can respond to infection and
cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant …

The fetus is considered to be an allograft that, paradoxically, survives pregnancy despite the
laws of classical transplantation immunology. There is no direct contact of the mother with …

Expression of the activating CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E
was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the …

KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …

Human natural killer (NK) cells express several killer cell immunoglobulin (Ig)-like receptors
(KIRs) that inhibit their cytotoxicity upon recognition of human histocompatibility leukocyte …