Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …

Parkinson's disease is the most common movement disorder, affecting about 1% of the
population over the age of 60 years. Parkinson's disease is characterized clinically by …

Objectives: Despite significant advances in neuroscience, the mechanisms of AD are not
fully understood. Single-cell RNA sequencing (scRNA-seq) techniques provide potential …

The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been
demonstrated in several studies. UNC0642, a specific and potent inhibitor of …

Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive
benefits. We have reported that CA water extract (CAW) treatment improves cognitive …

Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …

Brain-derived neurotrophic factor (BDNF), a protein belonging to the neurotrophin family, is
known to be heavily involved in synaptic plasticity processes that support brain …

Environmental enrichment (EE) is an experimental paradigm that is used to explore how a
complex, stimulating environment can impact overall health. In laboratory animal …

Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …

Abstract Trigonelline (TGN; 1-methylpyridin-1-ium-3-carboxylate) is a widely distributed
alkaloid derived from plants. Since we previously found a neurite outgrowth effect of TGN …