The plasma membrane phospholipid distribution of animal cells is markedly asymmetric.
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are concentrated in the inner …

Lipid-protein interactions are normally classified as either specific or general. Specific
interactions refer to lipid binding to specific binding sites within a membrane protein, thereby …

Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts
to uninfected cells, a process called trans-infection. Whether trans-infection contributes to …

The membrane-associated RING-CH (MARCH) proteins belong to a family of E3 ubiquitin
ligases, whose main function is to remove transmembrane proteins from the plasma …

ABSTRACT HIV-1 has to overcome physical barriers posed by host cell restriction factors
(RFs) for efficient replication. Some RFs, including Trim5α and tetherin, trigger antiviral …

Retroviruses spread more efficiently when infected and uninfected cells form tight, physical
interfaces known as virological synapses (VSs). VS formation is initiated by adhesive …

ABSTRACT HIV-1 incorporates various host membrane proteins during particle assembly at
the plasma membrane; however, the mechanisms mediating this incorporation process …

Viruses are pathogens that strictly depend on their host for propagation. Over years of co-
evolution viruses have become experts in exploiting the host cell biology and physiology to …

Clusters of positively-charged basic amino acid residues, particularly lysine, are known to
promote the interaction of many peripheral membrane proteins with the cytoplasmic surface …

ABSTRACT B and CD4+ T lymphocytes are natural targets of murine leukemia virus (MLV).
Migrating lymphocytes adopt a polarized morphology with a trailing edge designated the …