Insulin-like growth factor-1: a promising therapeutic target for peripheral nerve injury

BR Slavin, KA Sarhane, N von Guionneau… - … in bioengineering and …, 2021 - frontiersin.org
Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory
and motor loss. Presently, there is a lack of clinically available therapeutics that can be given …

Molecular pathogenesis and treatment of cavernous nerve injury-induced erectile dysfunction: a narrative review

G Song, P Hu, J Song, J Liu, Y Ruan - Frontiers in Physiology, 2022 - frontiersin.org
Introduction: Erectile dysfunction (ED) is a common complication after radical prostatectomy
(RP), and it seriously affects the quality of life in patients and their partners. The primary …

Sustain release of loaded insulin within biomimetic hydrogel microsphere for sciatic tissue engineering in vivo

V Zolfagharzadeh, J Ai, H Soltani… - International Journal of …, 2023 - Elsevier
We developed insulin loaded biomimetic microsphere by laccase-mediated crosslinking
using a microfluidic device in the water-in-oil emulsion system as an injectable vehicle for …

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

H Asker, D Yilmaz‐Oral, CV Oztekin, S Gur - The Prostate, 2022 - Wiley Online Library
Background Radical prostatectomy (RP) and radiation treatment are standard options for
localized prostate cancer. Even though nerve‐sparing techniques have been increasingly …

Simvastatin alleviated diabetes mellitus‐induced erectile dysfunction in rats by enhancing AMPK pathway‐induced autophagy

F Ding, C Shan, H Li, Y Zhang, C Guo, Z Zhou… - …, 2020 - Wiley Online Library
Background Diabetes mellitus‐induced erectile dysfunction is a common diabetic
complication, and new therapeutics and the pathogenesis of diabetes mellitus‐induced …

Intracavernous injection of autologous platelet-rich plasma ameliorates hyperlipidemia-associated erectile dysfunction in a rat model

YC Huang, CT Wu, MF Chen, YH Kuo, JM Li… - Sexual …, 2021 - academic.oup.com
Introduction Hyperlipidemia is associated with an increased risk of erectile dysfunction (ED)
mediated by endothelial damage. Platelet-rich plasma (PRP) contains numerous angiogenic …

Dual Strategy with Adipose-Derived Stem Cells and l-arginine Recovered Cavernosal Functions in a Rat Model of Radical Prostatectomy

D Yilmaz-Oral, SF Sezen, D Turkcan… - Stem Cells and …, 2024 - liebertpub.com
As standard therapy for prostate cancer, radical prostatectomy causes cavernous nerve (CN)
injury and increases fibrosis and hypoxia-induced penile structural alterations. This study …

Long-term consequences of bilateral cavernous crush injury in normal and diabetic rats: a functional study

F Castiglione, M Albersen, S Fiorenzo… - International journal of …, 2022 - nature.com
A recent statement from the European-Society-for-Sexual-Medicine has highlighted the
limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with …

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method

H Sun, W Luo, X Huang - Current Pharmaceutical Biotechnology, 2024 - benthamdirect.com
Protein/peptide drugs are extensively used to treat various chronic and serious diseases.
The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of …

Comparison of critical biomarkers in 2 erectile dysfunction models based on GEO and NOS-cGMP-PDE5 pathway

G Wang, D Shen, X Zhang, MG Ferrini, Y Li, H Liao - Medicine, 2021 - journals.lww.com
Background: Erectile dysfunction is a disease commonly caused by diabetes mellitus
(DMED) and cavernous nerve injury (CNIED). Bioinformatics analyses including …