The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
TJP Van Dam, G Wheway, GG Slaats… - Cilia, 2013 - Springer
The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the
cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive …
cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive …
The electrochemical basis of odor transduction in vertebrate olfactory cilia
SJ Kleene - Chemical senses, 2008 - academic.oup.com
Most vertebrate olfactory receptor neurons share a common G-protein–coupled pathway for
transducing the binding of odorant into depolarization. The depolarization involves 2 …
transducing the binding of odorant into depolarization. The depolarization involves 2 …
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs
Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent
infections of the upper and lower respiratory tract, reduced fertility in males and situs …
infections of the upper and lower respiratory tract, reduced fertility in males and situs …
Biallelic mutations in CFAP43 and CFAP44 cause male infertility with multiple morphological abnormalities of the sperm flagella
Sperm motility is vital to human reproduction. Malformations of sperm flagella can cause
male infertility. Men with multiple morphological abnormalities of the flagella (MMAF) have …
male infertility. Men with multiple morphological abnormalities of the flagella (MMAF) have …
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice
H Miyata, JM Castaneda, Y Fujihara… - Proceedings of the …, 2016 - National Acad Sciences
Gene-expression analysis studies from Schultz et al. estimate that more than 2,300 genes in
the mouse genome are expressed predominantly in the male germ line. As of their 2003 …
the mouse genome are expressed predominantly in the male germ line. As of their 2003 …
ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6
MA Zariwala, HY Gee, M Kurkowiak… - The American Journal of …, 2013 - cell.com
Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent
respiratory infections and male infertility. Using whole-exome resequencing and high …
respiratory infections and male infertility. Using whole-exome resequencing and high …
A molecular ruler determines the repeat length in eukaryotic cilia and flagella
Existence of cellular structures with specific size raises a fundamental question in biology:
How do cells measure length? One conceptual answer to this question is by a molecular …
How do cells measure length? One conceptual answer to this question is by a molecular …
Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia
E Kott, P Duquesnoy, B Copin, M Legendre… - The American Journal of …, 2012 - cell.com
Primary ciliary dyskinesia (PCD) is a group of autosomal-recessive disorders resulting from
cilia and sperm-flagella defects, which lead to respiratory infections and male infertility. Most …
cilia and sperm-flagella defects, which lead to respiratory infections and male infertility. Most …
ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry
The motive forces for ciliary movement are generated by large multiprotein complexes
referred to as outer dynein arms (ODAs), which are preassembled in the cytoplasm prior to …
referred to as outer dynein arms (ODAs), which are preassembled in the cytoplasm prior to …
Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia
Primary ciliary dyskinesia (PCD) is a ciliopathy characterized by airway disease, infertility,
and laterality defects, often caused by dual loss of the inner dynein arms (IDAs) and outer …
and laterality defects, often caused by dual loss of the inner dynein arms (IDAs) and outer …