Targeting PAI-1 in cardiovascular disease: structural insights into PAI-1 functionality and inhibition
M Sillen, PJ Declerck - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
Reactive centre loop dynamics and serpin specificity
Serine proteinase inhibitors (serpins), typically fold to a metastable native state and undergo
a major conformational change in order to inhibit target proteases. However, conformational …
a major conformational change in order to inhibit target proteases. However, conformational …
Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19
Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis
and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases …
and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases …
[HTML][HTML] Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction
M Sillen, SD Weeks, X Zhou, AA Komissarov… - Journal of Thrombosis …, 2020 - Elsevier
Background Plasminogen activator inhibitor‐1 (PAI‐1), a key inhibitor of plasminogen
activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a crucial role in …
activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a crucial role in …
Designing rt-PA Analogs to Release its Trapped Thrombolytic Activity
W Li - Journal of Computational Biophysics and Chemistry, 2021 - World Scientific
Recombinant tissue-type plasminogen activator (rt-PA, alteplase) is an FDA-approved
thrombolytic drug. Designing rt-PA analogs to suppress its inhibition by plasminogen …
thrombolytic drug. Designing rt-PA analogs to suppress its inhibition by plasminogen …
Label-Free Quantification based Proteomic Analysis of Serum Obtained from Henoch-Schonlein Purpura Patients before and after Zhenbao Pill Treatment
S Wang, C Gong, H Jin - Pakistan Journal of Zoology, 2023 - search.proquest.com
ABSTRACT Henoch-Schonlein Purpura (HSP), also known as immunoglobulin A vasculitis,
is an immune disorder that is predominantly seen in children (8-20/100000 each year) …
is an immune disorder that is predominantly seen in children (8-20/100000 each year) …
Label-free quantification based proteomic analysis of serum obtained from Henoch-Schönlein Purpura patients before and after Zhenbao pill treatment.
Wuritunashun, Burenbatu, Narenqiqige, Jiuguniang… - 2023 - cabidigitallibrary.org
Abstract Henoch-Schönlein Purpura (HSP), also known as immunoglobulin A vasculitis, is
an immune disorder that is predominantly seen in children (8-20/100000 each year) …
an immune disorder that is predominantly seen in children (8-20/100000 each year) …
Фибринолитическая система в опухоли и прилежащих тканях при плоскоклеточном раке пищевода у мужчин
ОИ Кит, ЕМ Франциянц, ЛС Козлова… - … проблемы науки и …, 2017 - elibrary.ru
Молекулярный механизм, лежащий в основе метастазирования–метаболическая
перестройка и разрушение окружающих опухоль структур ассоциированными с ней …
перестройка и разрушение окружающих опухоль структур ассоциированными с ней …
[PDF][PDF] Structural analysis of antibody-based and small molecule profibrinolytics
M SILLEN - 2021 - lirias.kuleuven.be
STRUCTURAL ANALYSIS OF ANTIBODY-BASED AND SMALL MOLECULE
PROFIBRINOLYTICS Page 1 KU Leuven Biomedical Sciences Group Department of …
PROFIBRINOLYTICS Page 1 KU Leuven Biomedical Sciences Group Department of …
Активаторы плазминогена и PAI-1 в тканях аденокарциномы и плоскоклеточного рака пищевода
ОИ Кит, ЕН Колесников, ЕМ Франциянц… - Российский …, 2016 - cyberleninka.ru
Цель изучение компонентов системы активации плазминогена uPA, tPA, их ингибитора
PAI-1 в тканях аденокарциномы (АК) и плоскоклеточного рака пищевода (ПР) в …
PAI-1 в тканях аденокарциномы (АК) и плоскоклеточного рака пищевода (ПР) в …