Introduction: Over the past decades, neuroimaging studies have clarified that a significant
proportion of patients with sickle cell disease (SCD) have functionally significant brain …

Background Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by
abnormal hemoglobin molecules, which includes numerous acute and chronic …

Objective The purpose of this retrospective cross-sectional study was to investigate whether
changes in white matter integrity are related to slower processing speed in sickle cell …

It is well-established that patients with sickle cell disease (SCD) are at substantial risk of
neurological complications, including overt and silent stroke, microstructural injury, and …

Severe chronic anemia is an independent predictor of overt stroke, white matter damage,
and cognitive dysfunction in the elderly. Severe anemia also predisposes to white matter …

Anemia is the most common blood disorder in the world. In patients with chronic anemia,
such as sickle cell disease or major thalassemia, cerebral blood flow increases to …

Although modern medical management has lowered overt stroke occurrence in patients with
sickle cell disease (SCD), progressive white matter (WM) damage remains common. It is …

Sickle cell disease (SCD) is caused by a single amino acid mutation in hemoglobin, causing
chronic anemia and neurovascular complications. However, the effects of chronic anemia on …

Research in sickle cell anemia (SCA) has used, with limited race-matched control data,
binary categorization of patients according to the presence or absence of silent cerebral …

The long‐term use of opioids leads alternations in both innate‐adaptive immune systems
and other diagnostic hematologic cells. The purpose of this study is to evaluate the …