Antimicrobial peptides—Mechanisms of action, antimicrobial effects and clinical applications

J Talapko, T Meštrović, M Juzbašić, M Tomas, S Erić… - Antibiotics, 2022 - mdpi.com
The growing emergence of antimicrobial resistance represents a global problem that not
only influences healthcare systems but also has grave implications for political and …

Approaches to dispersing medical biofilms

D Fleming, KP Rumbaugh - Microorganisms, 2017 - mdpi.com
Biofilm-associated infections pose a complex problem to the medical community, in that
residence within the protection of a biofilm affords pathogens greatly increased tolerances to …

Targeting biofilms therapy: current research strategies and development hurdles

Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …

Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names

AP Douglass, B Offei, S Braun-Galleani… - PLoS …, 2018 - journals.plos.org
We investigated genomic diversity of a yeast species that is both an opportunistic pathogen
and an important industrial yeast. Under the name Candida krusei, it is responsible for about …

Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida

Y Lyu, Y Yang, X Lyu, N Dong, A Shan - Scientific reports, 2016 - nature.com
Antimicrobial peptides (AMPs) have recently attracted a great deal of attention as promising
antibiotic candidates, but some obstacles such as toxicity and high synthesis cost must be …

Membrane-interacting antifungal peptides

C Struyfs, BPA Cammue, K Thevissen - Frontiers in cell and …, 2021 - frontiersin.org
The incidence of invasive fungal infections is increasing worldwide, resulting in more than
1.6 million deaths every year. Due to growing antifungal drug resistance and the limited …

Antifungal peptides: To be or not to be membrane active

M Rautenbach, AM Troskie, JA Vosloo - Biochimie, 2016 - Elsevier
Most antifungal peptides (AFPs), if not all, have membrane activity, while some also have
alternative targets. Fungal membranes share many characteristics with mammalian …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

Antimicrobial Peptides with Anti-Candida Activity

A Perez-Rodriguez, E Eraso, G Quindós… - International journal of …, 2022 - mdpi.com
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …

Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris

IA Rather, JSM Sabir, AH Asseri, S Ali - Journal of Fungi, 2022 - mdpi.com
Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing
severe invasive infections associated with high mortality rates in hospitalized individuals …