Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α)
and beta (β) subunits arranged in numerous dimeric pairings. These complexes have …

Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Integrins are heterodimeric transmembrane adhesion receptors that couple the actin
cytoskeleton to the extracellular environment and bidirectionally relay signals across the cell …

Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and
enabling cells to migrate and resist mechanical force. Talin is an intracellular protein that is …

Cell adhesion requires linkage of transmembrane receptors to the cytoskeleton through
intermediary linker proteins. Integrin-based adhesion to the extracellular matrix (ECM) …

Cell growth depends upon formation of cell–matrix adhesions, but mechanisms detailing the
transmission of signals from adhesions to control proliferation are still lacking. Here, we find …

Nascent adhesions are submicron transient structures promoting the early adhesion of cells
to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins …

Talin-1 is a key component of the multiprotein adhesion complexes which mediate cell
migration, adhesion and integrin signalling and has been linked to cancer in several studies …

Attachment of cells to the extracellular matrix (ECM) via integrins is essential for animal
development and tissue maintenance. The cytoplasmic protein Talin (encoded by rhea in …

Cell membrane roughness has been proposed as a sensitive feature to reflect cellular
physiological conditions. In order to know whether membrane roughness is associated with …