Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

[HTML][HTML] The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases

K Chen, W Gong, J Huang, T Yoshimura… - Frontiers in Bioscience …, 2021 - imrpress.com
Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived
from its precursor protein hCAP18, which is an only cathelicidin in human. LL-37 not only …

Combating drug-resistant fungi with novel imperfectly amphipathic palindromic peptides

J Wang, S Chou, Z Yang, Y Yang, Z Wang… - Journal of medicinal …, 2018 - ACS Publications
Antimicrobial peptides are an important weapon against invading pathogens and are
potential candidates as novel antibacterial agents, but their antifungal activities are not fully …

Joker: An algorithm to insert patterns into sequences for designing antimicrobial peptides

WF Porto, ICM Fensterseifer, SM Ribeiro… - Biochimica et Biophysica …, 2018 - Elsevier
Innovative alternatives to control bacterial infections are need due to bacterial resistance
rise. Antimicrobial peptides (AMPs) have been considered as the new generation of …

Design of heptad repeat amphiphiles based on database filtering and structure–function relationships to combat drug-resistant fungi and biofilms

P Tan, Z Lai, Q Jian, C Shao, Y Zhu, G Li… - ACS applied materials …, 2019 - ACS Publications
Due to the emergence of reports of multidrug-resistant fungi, infections caused by multidrug-
resistant fungi and biofilms are considered to be a global threat to human health due to the …

Short symmetric-end antimicrobial peptides centered on β-turn amino acids unit improve selectivity and stability

N Dong, S Chou, J Li, C Xue, X Li, B Cheng… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are excellent candidates to combat the increasing number of
multi-or pan-resistant pathogens worldwide based on their mechanism of action, which is …

Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria

ICM Fensterseifer, MR Felicio, ESF Alves… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Infections caused by Gram-negative bacteria, Escherichia coli and Pseudomonas
aeruginosa foremost among them, constitute a major worldwide health problem …

Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and …

D Pratap Verma, MM Ansari, NK Verma… - Journal of Medicinal …, 2021 - ACS Publications
To design novel antimicrobial peptides by utilizing the sequence of the human host defense
protein, chemerin, a seven-residue amphipathic stretch located in the amino acid region …

[HTML][HTML] MM-GBSA and QM/MM simulation-based in silico approaches for the inhibition of Acinetobacter baumannii class D OXA-24 β-lactamase using antimicrobial …

M Mandal, S Mandal - Chemical Physics Impact, 2024 - Elsevier
The antimicrobial peptides (AMPs) have been regarded as the next generation antibiotics.
This study aimed to explore the AMP inhibitors of β-lactamase enzyme employing …

Anti-Protozoan Activities of Polar Fish-Derived Polyalanine Synthetic Peptides

EAC Nunes, MC da Silva, MH Cardoso, SLE Preza… - Marine Drugs, 2023 - mdpi.com
Chagas disease, sleeping sickness and malaria are infectious diseases caused by
protozoan parasites that kill millions of people worldwide. Here, we performed in vitro …