Recent development in indole derivatives as anticancer agent: A mechanistic approach

N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

Recent development in indole derivatives as anticancer agents for breast cancer

K Kaur, V Jaitak - Anti-Cancer Agents in Medicinal Chemistry …, 2019 - ingentaconnect.com
Background: Breast Cancer (BC) is the second most common cause of cancer related
deaths in women. Due to severe side effects and multidrug resistance, current therapies like …

Copper (II) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells

A Sîrbu, O Palamarciuc, MV Babak, JM Lim… - Dalton …, 2017 - pubs.rsc.org
A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid
thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) …

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase …

JF de Oliveira, TS Lima, DB Vendramini-Costa… - European journal of …, 2017 - Elsevier
In this study, we report the synthesis and structural characterization of a series of
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …

Potential anticancer agents against melanoma cells based on an as-synthesized thiosemicarbazide derivative

P Kozyra, A Korga-Plewko, Z Karczmarzyk, A Hawrył… - Biomolecules, 2022 - mdpi.com
In this paper, thiosemicarbazide derivatives were synthesized as potential anticancer
agents. X-ray investigations for 1-(2, 4-dichlorophenoxy) acetyl-4-(2-fluorophenyl) …

Thiosemicarbazone complexes as versatile medicinal chemistry agents: a review

EJ Siddiqui, I Azad, AR Khan, T Khan - Journal of drug delivery and …, 2019 - jddtonline.info
Objective: Thiosemicarbazones are Schiff based ligands of significant biological importance
and their biological relevance has been studied for a considerable amount of time period …

Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives

M Pitucha, M Woś, M Miazga-Karska, K Klimek… - Medicinal Chemistry …, 2016 - Springer
In this study, the antibacterial, cytotoxic and antiproliferative activities of novel
thiosemicarbazide derivatives were assessed. Our results demonstrated that some of the …

Copper (I) and silver (I) complexes of anthraldehyde thiosemicarbazone: Synthesis, structure elucidation, in vitro anti-tuberculosis/cytotoxic activity and interactions …

A Khan, K Paul, I Singh, JP Jasinski… - Dalton …, 2020 - pubs.rsc.org
A reaction of copper (I) halides (X= I, Br, Cl) and silver (I) halides with 9-anthraldehyde
thiosemicarbazone (9-Hanttsc, H1L) and triphenylphosphine produced halogen-bridged …

Strong effect of copper (II) coordination on antiproliferative activity of thiosemicarbazone–piperazine and thiosemicarbazone–morpholine hybrids

F Bacher, O Dömötör, A Chugunova, NV Nagy… - Dalton …, 2015 - pubs.rsc.org
In this study, 2-formylpyridine thiosemicarbazones and three different heterocyclic
pharmacophores were combined to prepare thiosemicarbazone–piperazine mPip-FTSC …

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

YK Abhale, A Shinde, KK Deshmukh, L Nawale… - Medicinal Chemistry …, 2017 - Springer
The increase in antibiotic resistance due to multiple factors has warranted the need for
search of new compounds which are active against multidrug resistant pathogens. In this …