Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the
parasite through the tissues of its host, and also participate in functions such as feeding and …

Many parasites have deployed proteinases to accomplish some of the tasks imposed by a
parasitic life style, including tissue penetration, digestion of host tissue for nutrition and …

The potential of different parasite proteinases for use as vaccine candidates against
fascioliasis in sheep was studied by vaccinating animals with the cathepsin L proteinases …

The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following
ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge …

Infection of ruminants by Fasciola spp continues to cause large economic losses worldwide.
Recent results from several laboratories have demonstrated that animals can be significantly …

Probing protein function in parasitic flatworms is hampered by the difficulties associated with
the development of transgenic approaches. Although RNA interference (RNAi) in …

The secretion and activation of the major cathepsin L1 cysteine protease involved in the
virulence of the helminth pathogen Fasciola hepatica was investigated. Only the fully …

La facilité d'obtenir de la nourriture est probablement le principal facteur de pression
sélective qui anime et maintient la relation hôte–parasite. La fonction alimentaire des …