With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have
been independently described in many tumour types, including hepatocellular carcinoma …

Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly
malignant, recurrent, drug‐resistant, and often diagnosed in the advanced stage. It is clear …

In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target
in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in …

Hepatocellular carcinoma is today the sixth leading cause of cancer-related death
worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the …

Hepatocellular carcinoma (HCC) is an aggressive and widespread cancer. Patients with
liver cirrhosis of different aetiologies are at a risk to develop HCC. It is important to know that …