Investigating freezing-induced acidity changes in citrate buffers
Citrate buffers are commonly utilized in the field of biomolecule stabilization. We investigate
their applicability in the frozen state within a range of initial pHs (2.5 to 8.0) and …
their applicability in the frozen state within a range of initial pHs (2.5 to 8.0) and …
Freezing-induced acidification of sea ice brine
The acidity of sea ice and snow plays a key role in the chemistry of the cryosphere; an
important example lies in the photochemical catalytic release of reactive bromine in polar …
important example lies in the photochemical catalytic release of reactive bromine in polar …
Probing Chemical Equilibrium in Frozen Sodium Phosphate Buffer Solution by 31P Solid-State NMR
Phosphate buffers are crucial for cryopreservative stability in pharmaceuticals, food
processing, biomedical sciences, and biology. However, their freeze concentrates lack …
processing, biomedical sciences, and biology. However, their freeze concentrates lack …
Impact of secondary ice in a frozen NaCl freeze-concentrated solution on the extent of methylene blue aggregation
Freezing and lyophilization have been utilized for decades to stabilize pharmaceutical and
food products. Freezing a solution that contains dissolved salt and/or organic matter …
food products. Freezing a solution that contains dissolved salt and/or organic matter …
Determination of Solid-State Acidity of Lyophilized Trehalose Containing Citrate, Phosphate, and Histidine Buffers Using UV/VIS Diffuse Reflectance and Solid-State …
Abstract Changes in the protonation state of lyophilized proteins can impact structural
integrity, chemical stability, and propensity to aggregate upon reconstitution. When a buffer …
integrity, chemical stability, and propensity to aggregate upon reconstitution. When a buffer …
Molecular Mechanisms for Stabilizing Biologics in the Solid State
Protein drugs exhibit challenges of biophysical and biochemical instability due to their
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …