Human axial progenitors generate trunk neural crest cells in vitro
TJR Frith, I Granata, M Wind, E Stout, O Thompson… - Elife, 2018 - elifesciences.org
The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell
types in an axial position-dependent manner. The production of NC cells from human …
types in an axial position-dependent manner. The production of NC cells from human …
Biomechanical coupling facilitates spinal neural tube closure in mouse embryos
Neural tube (NT) formation in the spinal region of the mammalian embryo involves a wave of
“zippering” that passes down the elongating spinal axis, uniting the neural fold tips in the …
“zippering” that passes down the elongating spinal axis, uniting the neural fold tips in the …
Regulation of cell protrusions by small GTPases during fusion of the neural folds
A Rolo, D Savery, S Escuin, SC de Castro, HEJ Armer… - Elife, 2016 - elifesciences.org
Epithelial fusion is a crucial process in embryonic development, and its failure underlies
several clinically important birth defects. For example, failure of neural fold fusion during …
several clinically important birth defects. For example, failure of neural fold fusion during …
Oct4 is a key regulator of vertebrate trunk length diversity
Vertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the
evolutionary and developmental origins of this diversity remain largely unknown. Posterior …
evolutionary and developmental origins of this diversity remain largely unknown. Posterior …
Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cells in vitro
L Verrier, L Davidson, M Gierliński, A Dady… - …, 2018 - journals.biologists.com
Robust protocols for directed differentiation of human pluripotent cells are required to
determine whether mechanisms operating in model organisms are relevant to our own …
determine whether mechanisms operating in model organisms are relevant to our own …
Genetic approaches in mice demonstrate that neuro-mesodermal progenitors express T/Brachyury but not Sox2
D Mugele, DA Moulding, D Savery, MA Molè… - BioRxiv, 2018 - biorxiv.org
Neural tube and somites have long been thought to derive from separate germ layers: the
ectoderm and mesoderm. This concept was challenged by the discovery of neuro …
ectoderm and mesoderm. This concept was challenged by the discovery of neuro …
Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse
I Mastromina, L Verrier, JC Silva, KG Storey… - …, 2018 - journals.biologists.com
The Myc transcriptional regulators are implicated in a range of cellular functions, including
proliferation, cell cycle progression, metabolism and pluripotency maintenance. Here, we …
proliferation, cell cycle progression, metabolism and pluripotency maintenance. Here, we …
Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro
L Verrier, L Davidson, M Gierliński, KG Storey - bioRxiv, 2017 - biorxiv.org
Robust protocols for directed differentiation of human pluripotent cells are needed to
establish the extent to which mechanisms operating in model organisms are relevant to our …
establish the extent to which mechanisms operating in model organisms are relevant to our …
Role of neuro-mesodermal progenitors in neural tube formation
D Mugele - 2018 - discovery.ucl.ac.uk
It has long been thought that neural tube and somites derive from different germ layers,
namely the ectoderm and mesoderm. This paradigm was challenged by the discovery of a …
namely the ectoderm and mesoderm. This paradigm was challenged by the discovery of a …
MYC activity is required for maintenance of the Neuromesodermal Progenitor signalling network and for correct timing of segmentation clock gene oscillations
I Mastromina, L Verrier, KG Storey, JK Dale - bioRxiv, 2017 - biorxiv.org
The Myc transcriptional regulators are implicated in a range of cellular functions, including
proliferation, cell cycle progression, metabolism and pluripotency maintenance. Here, we …
proliferation, cell cycle progression, metabolism and pluripotency maintenance. Here, we …