Skeletal tissue development and regeneration in mammals are intricate, multistep, and
highly regulated processes. Various signaling pathways have been implicated in the …

Cellular biomanufacturing technologies are a critical link to the successful application of cell
and scaffold based regenerative therapies, organs-on-chip devices, disease models and …

Duchenne muscular dystrophy (DMD), caused by mutations at the dystrophin gene, is the
most common form of muscular dystrophy. There is no cure for DMD and current therapeutic …

Background Notch signaling plays important roles in regulating innate immunity. However,
little is known about the role of Notch in mesenchymal stromal/stem cell (MSC)-mediated …

Notch is an important pathway in that it regulates cell-to-cell signal transduction, which plays
an essential role in skeletal remodeling. Bone morphogenetic protein (BMP) 9 has been …

The development from stem cells to adult tissues requires the delicate presentation of
numerous crucial inductive cues and the activation of associated signaling pathways. The …

Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs)
in the embryo and their development in the fetal liver niche. However, how Notch signaling …

Background: Bone fragility and related fractures are increasingly being recognized as an
important diabetic complication. Mesenchymal progenitors often serve as an important …

Background There is growing evidence that extracellular vesicles (EVs) play a crucial role in
the paracrine mechanisms of transplanted human mesenchymal stem cells (hMSCs). Little is …

Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell
(MSC) monolayer sheet transplantation on allograft repair. A limiting factor in their …