Neuromuscular junction dysfunction in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
Nutritional and metabolic factors in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …
classically thought to impact the motor system. Over the past 20 years, research has started …
SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle atrophy and paralysis. To date, multiple panels of …
motor neuron degeneration, muscle atrophy and paralysis. To date, multiple panels of …
Skeletal muscle in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, has been
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …
Neuromuscular junction as an entity of nerve-muscle communication
One of the crucial systems severely affected in several neuromuscular diseases is the loss of
effective connection between muscle and nerve, leading to a pathological non …
effective connection between muscle and nerve, leading to a pathological non …
BDNF-dependent modulation of axonal transport is selectively impaired in ALS
Axonal transport ensures long-range delivery of essential cargoes between proximal and
distal compartments, and is needed for neuronal development, function, and survival …
distal compartments, and is needed for neuronal development, function, and survival …
Skeletal muscle in ALS: an unappreciated therapeutic opportunity?
S Scaricamazza, I Salvatori, A Ferri, C Valle - Cells, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
selective degeneration of upper and lower motor neurons and by the progressive weakness …
selective degeneration of upper and lower motor neurons and by the progressive weakness …
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice
S Scaricamazza, I Salvatori, S Amadio… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
[HTML][HTML] Skeletal-muscle metabolic reprogramming in ALS-SOD1G93A mice predates disease onset and is a promising therapeutic target
S Scaricamazza, I Salvatori, G Giacovazzo, JP Loeffler… - IScience, 2020 - cell.com
Patients with ALS show, in addition to the loss of motor neurons in the spinal cord,
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …