Intracellular pH (pHi) is an important modulator of cardiac excitation and contraction, and a
potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane …

Chronic stimulation of the β1-adrenergic receptor leads to hypertrophy and heart failure in
β1-adrenergic receptor transgenic mice and contributes to disease progression in heart …

Overload of neonatal and adult cardiomyocytes and mul-ticellular myocardial preparations,
which include whole hearts, are accompanied by an enhanced activity of the Na+/H+ …

Cardiac hypertrophy is often associated with an increased sympathetic drive, and both in
vitro and in vivo studies have demonstrated the development of cardiomyocyte hypertrophy …

Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in
diverse biological processes. Among these are photosynthesis, the Krebs cycle, whole-body …

The Na+/H+ exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher
eukaryotes this integral membrane protein removes one intracellular H+ for one extracellular …

Na–H exchange (NHE) is the primary process by which the cardiac cell extrudes protons
particularly under conditions of intracellular acidosis. Nine isoforms of NHE have now been …

Background—ACE inhibitors (ACEIs) and angiotensin II type 1 (AT1) receptor blockers are
effective in reducing left ventricular mass in hypertension and heart failure. However, the …

Na+/H+ exchange (NHE) represents a major mechanism for intracellular pH regulation,
particularly in the ischemic myocardium. NHE has also been shown to be important in the …

Objective: Experiments were performed to examine the effect of chronic inhibition of the
Na+/H+ exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously …