Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

J Guo, Z Xie, W Ruan, Q Tang, D Qiao, W Zhu - European Journal of …, 2023 - Elsevier
In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Polyphenols as inhibitors of antibiotic resistant bacteria—Mechanisms underlying rutin interference with bacterial virulence

M Ivanov, K Novović, M Malešević, M Dinić… - Pharmaceuticals, 2022 - mdpi.com
The rising incidence of antibiotic resistant microorganisms urges novel antimicrobials
development with polyphenols as appealing potential therapeutics. We aimed to reveal the …

The bioactivity of thiazolidin-4-ones: A short review of the most recent studies

D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …

Newly synthesized imidazolotriazole, imidazolotriazine, and imidazole-pyrazole hybrid derivatives as promising antimicrobial agents

M El-Shahat, WI El-Sofany, AGA Soliman… - Journal of Molecular …, 2022 - Elsevier
Abstract Novel 1-(3-(4-bromophenyl)-5-methyl-2-thioxo-2, 3-dihydro-1H-imidazol-4-yl) ethan-
1-one 1 was synthesized through a one-step reaction and allowed to react with ethyl …

Triazolo based-thiadiazole derivatives. Synthesis, biological evaluation and molecular docking studies

C Kamoutsis, M Fesatidou, A Petrou, A Geronikaki… - Antibiotics, 2021 - mdpi.com
The goal of this research is to investigate the antimicrobial activity of nineteen previously
synthesized 3, 6-disubstituted-1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazole derivatives. The …

Thiazolidin-4-ones as a promising scaffold in the development of antibiofilm agents—A review

N Trotsko - International Journal of Molecular Sciences, 2023 - mdpi.com
Thiazolidin-4-ones have a broad range of medical and clinical implementation, which is
important for pharmaceutical and medicinal chemistry. This heterocyclic core has been …

Discovery of benzothiazole-based thiazolidinones as potential anti-inflammatory agents: Anti-inflammatory activity, soybean lipoxygenase inhibition effect and …

M Haroun, A Petrou, C Tratrat, K Kositsi… - SAR and QSAR in …, 2022 - Taylor & Francis
Despite the greatest achievement in the development of anti-inflammatory agents in the last
two decades, the current clinical drugs suffer from a variety of complications in community …

Evaluating the Antivirulence Effects of New Thiazolidinedione Compounds Against Pseudomonas aeruginosa PAO1

N Shakour, E Taheri, F Rajabian, S Tarighi… - Microbial Drug …, 2022 - liebertpub.com
Pseudomonas aeruginosa is an opportunistic pathogen that causes several serious health
problems and numerous forms of virulence. During the treatment of P. aeruginosa infections …

Synthesis, crystal structure, Hirshfeld surface, energy framework, NCI-RDG, theoretical calculations and molecular docking of (Z) 4, 4′-bis [-3-N-ethyl-2-N' …

ZD Benyahlou, FT Baara, S Yahiaoui… - Journal of Molecular …, 2023 - Elsevier
The current study focuses first on the synthesis of a new organic heterocyclic compound.
The (Z) 4, 4′-bis [-3-N-ethyl-2-N'-(phenylimino) thiazolidin-4-one] methane (2-EPTh) was …