Cancer is a genetic disease where genetic variations cause abnormally functioning genes
that appear to alter expression. Proteins, the final products of gene expression, determine …

Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …

RNA-seq by poly (A) selection is currently the most common protocol for whole
transcriptome sequencing as it provides a broad, detailed, and accurate view of the RNA …

There are many instances in genomics data analyses where measurements are made on a
multivariate response. For example, alternative splicing can lead to multiple expressed …

Alternative splicing plays an essential role in many cellular processes and bears major
relevance in the understanding of multiple diseases, including cancer. High-throughput RNA …

Background RNA-seq has been a boon to the quantitative analysis of transcriptomes. A
notable application is the detection of changes in transcript usage between experimental …

Fuchs endothelial corneal dystrophy (FECD) is an inherited degenerative disease that
affects the internal endothelial cell monolayer of the cornea and can result in corneal edema …

Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the
potential to induce weight loss and to prevent obesity. Here, we document a …

Background In spite of many years of research, our understanding of the molecular bases of
Alzheimer's disease (AD) is still incomplete, and the medical treatments available mainly …