Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and
antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the …

Chrysin is a promising phytochemical that is categorized under the class of flavonoids based
on its chemical structure. Naturally, it is widely present in propolis, honey, passion fruit, and …

Background With the increasing ages of the general population, the incidence of knee
osteoarthritis (KOA) is also rising, and KOA has become a major health problem worldwide …

Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The
nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and …

Osteoarthritis (OA) is the most common degenerative joint disease characterized by
enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and …

Objective: Synovitis and fibrosis are common pathological features of knee osteoarthritis
(KOA). The interaction of synovitis and fibrosis can promote KOA progression. Chrysin …

Purpose Our recent reports have revealed that inhibiting NLRP3 activation reduces synovial
inflammation and fibrosis in knee osteoarthritis (KOA). Synovial inflammation is involved the …

Osteoarthritis (OA), an age-related degenerative disease, is characterized by progressive
degradation of the articular cartilage. There is increasing evidence that nobiletin (NOB) …

Recent reports imply that drug delivery approaches aimed to modulate the phenotypic and
functional switching of macrophages towards anti-inflammatory (M2) phenotypes have a …