A mammalian cell houses two genomes located separately in the nucleus and mitochondria.
During evolution, communications and adaptations between these two genomes occur …

Squamous cell carcinoma of the oral (mobile) tongue (OTSCC) is increasingly regarded as a
biologically different entity compared to cancer affecting other oral sites. It is more …

The incidence of oral cancer remains high and is associated with many deaths in both
Western and Asian countries. Several risk factors for the development of oral cancer are now …

Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …

Ionizing radiation (IR) began to be a powerful medical modality soon after Wilhelm
Röntgen's discovery of X-rays in 1895. Today, more than 50% of cancer patients receive …

Background: Cyclin B1 has an important role in the G 2–M phase transition of the cell cycle.
Wee1 delays mitosis by suppressing the activity of the Cyclin B1/cdc2 complex. The …

The management of adrenocortical tumors (ACTs) is complex. The Weiss score is the
present most widely used system for ACT diagnosis. An ACT is scored from 0 to 9, with a …

Cyclin B1 is the regulatory subunit of cyclin-dependent kinase 1 (Cdk1) and is critical for the
initiation of mitosis. Accumulating data indicate that the deregulation of cyclin B1 is tightly …

The cyclin B1–Cdk1 complex is a key regulator of mitotic entry. A large number of proteins
are phosphorylated by the cyclin B1–Cdk1 complex prior to mitotic entry. Regulation of the …

Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative
activities. However, the mechanisms by which Cud C induced cytotoxicity have yet to be fully …