[HTML][HTML] A comprehensive review of HER2 in cancer biology and therapeutics
X Cheng - Genes, 2024 - mdpi.com
Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane
glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial …
glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial …
Monoclonal antibodies for the treatment of cancer
JT Pento - Anticancer research, 2017 - ar.iiarjournals.org
The ability of cancer cells to evade the immune system is one of the most deadly
characteristics of the majority of malignant tumours. Accordingly, the recent development of …
characteristics of the majority of malignant tumours. Accordingly, the recent development of …
A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response
G Gambardella, G Viscido, B Tumaini, A Isacchi… - Nature …, 2022 - nature.com
Cancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic
plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response …
plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response …
Breast cancer‐derived exosomes reflect the cell‐of‐origin phenotype
A manner in which cells can communicate with each other is via secreted nanoparticles
termed exosomes. These vesicles contain lipids, nucleic acids, and proteins, and are said to …
termed exosomes. These vesicles contain lipids, nucleic acids, and proteins, and are said to …
A Multi-Center Clinical Study to Harvest and Characterize Circulating Tumor Cells from Patients with Metastatic Breast Cancer Using the Parsortix® PC1 System
EN Cohen, G Jayachandran, RG Moore, M Cristofanilli… - Cancers, 2022 - mdpi.com
Simple Summary There is a great need to understand the cellular and molecular
characteristics of cancer when access to the tumor is limited. Circulating tumor cells (CTCs) …
characteristics of cancer when access to the tumor is limited. Circulating tumor cells (CTCs) …
PillarX: a microfluidic device to profile circulating tumor cell clusters based on geometry, deformability, and epithelial state
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and
worse patient prognosis, but are rare, difficult to count, and poorly characterized …
worse patient prognosis, but are rare, difficult to count, and poorly characterized …
Benchmarking to the gold standard: hyaluronan‐oxime hydrogels recapitulate xenograft models with in vitro breast cancer spheroid culture
Many 3D in vitro models induce breast cancer spheroid formation; however, this alone does
not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is …
not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is …
The GRHL2/ZEB feedback loop—a key axis in the regulation of EMT in breast cancer
More than 90% of cancer‐related deaths are caused by metastasis. Epithelial‐to‐
Mesenchymal Transition (EMT) causes tumor cell dissemination while the reverse process …
Mesenchymal Transition (EMT) causes tumor cell dissemination while the reverse process …
[HTML][HTML] Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways
P Garrido, A Shalaby, EM Walsh, N Keane, M Webber… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Inflammation is implicated in triple negative breast cancer (TNBC) progression. TNBC
carries a worse prognosis than other breast cancer subtypes, and with the clinical and …
carries a worse prognosis than other breast cancer subtypes, and with the clinical and …
HER2 in breast cancer stemness: A negative feedback loop towards trastuzumab resistance
HER2 receptor tyrosine kinase that is overexpressed in approximately 20% of all breast
cancers (BCs) is a poor prognosis factor and a precious target for BC therapy. Trastuzumab …
cancers (BCs) is a poor prognosis factor and a precious target for BC therapy. Trastuzumab …