The aim of the present study was to determine the correlation between bone volume density
(BV/TV) around a titanium implant determined by micro-computed tomography (micro-CT) …

We completed a systematic literature review of in vivo animal models that use arthrotomy‐
based methods to study particle‐induced peri‐implant osteolysis. The purpose of the review …

Total joint replacements (TJR) are costly procedures required to relieve pain and restore
function in patients suffering from end-stage arthritis. Despite great progress in the …

Background Aseptic loosening around the prosthesis is a common cause of failure in total
joint arthroplasty. Polyethylene wear particles trigger the release of inflammatory factors by …

Background and Purpose Aseptic prosthesis loosening, caused by wear particles, is one of
the most common causes of arthroplasty failure. Extensive and over‐activated osteoclast …

Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint
arthroplasty failure, which occurs as a result of chronic inflammatory response and …

Implant-generated particle wears are considered as the major cause for the induction of
implant loosening, which is more susceptible to patients with osteoporosis. Monotherapy …

Periprosthetic asepteic loosening, caused by wear debris, is one of the most severe
complications, generally resulting in implant failure. Extensive osteoclast formation and …

Particle‐induced implant loosening is a major challenge to long‐term survival of joint
prostheses. Administration of intermittent parathyroid hormone (PTH) has shown potential in …

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