Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-
associated gene Cas9 represent an invaluable system for the precise editing of genes in …

The red flour beetle Tribolium castaneum has emerged as an important insect model system
for a variety of topics. With respect to studying gene function, it is second only to the vinegar …

Gene-editing techniques are revolutionizing the way we conduct genetics in many
organisms. The CRISPR/Cas nuclease has emerged as a highly versatile, efficient and …

Background The red flour beetle Tribolium castaneum has emerged as an important model
organism for the study of gene function in development and physiology, for ecological and …

MicroRNAs (miRNA) are a class of endogenous regulatory RNA molecules 21–24
nucleotides in length that modulate gene expression at the post-transcriptional level via …

Genetic screens are powerful tools to identify the genes required for a given biological
process. However, for technical reasons, comprehensive screens have been restricted to …

This review focuses on the state of the art on neuropeptide receptors in insects. Most of
these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation …

Background Insect pest control is challenged by insecticide resistance and negative impact
on ecology and health. One promising pest specific alternative is the generation of …

More than half of all extant metazoan species on earth are insects. The evolutionary success
of insects is linked with their ability to osmoregulate, suggesting that they have evolved …

Highlights•AA/TOR pathway regulates synthesis and secretion of ILPs as shown for
Drosophila.•ILPs represent a second nutritional checkpoint in regulation of …