The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …

Background Estimating and accounting for hidden variables is widely practiced as an
important step in molecular quantitative trait locus (molecular QTL, henceforth “QTL”) …

Metabolomics-based genome-wide association studies (mGWAS) are key to understanding
the genetic regulations of metabolites in complex phenotypes. We previously developed …

Deciphering the fine-scale molecular mechanisms that shape the genetic effects at disease-
associated loci from genome-wide association studies (GWAS) remains challenging. The …

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants
and their underlying molecular mechanisms remain largely unknown. Through systematic …

The global rate of wildlife extinctions is accelerating, and the persistence of many species
requires conservation breeding programs. A central paradigm of these programs is to …

Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …