Increasing ecological validity in neuropsychopharmacology research on the relationship between alcohol use and uncertain stressors

DE Bradford, AS Dev, A DeFalco, F Whittaker… - …, 2024 - nature.com
We enthusiastically read Gorka et al.[1]. Earlier laboratory work from both their group and
authors of this letter (eg, refs.[2, 3]) highlight stressor uncertainty as a key moderator of …

Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence

NL Zabik, EA Flook, B Feola… - Alcohol: Clinical and …, 2024 - Wiley Online Library
Background Anxiety during early alcohol abstinence, likely resulting from neural changes
caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show …

Drawbacks to strengthening neural salience encoding: a link between cortisol and risky drinking

BB Harris, R Sinha, EV Goldfarb - Journal of Neuroscience, 2024 - jneurosci.org
Emotionally salient experiences are encoded and remembered more strongly, an effect that
can be amplified by hormones like cortisol. Such memories can in turn profoundly influence …

Neurostructural features predict binge drinking in emerging adulthood: Evidence from a 5-year follow-up study

JM Pérez-García, S Suárez-Suárez… - Drug and Alcohol …, 2024 - Elsevier
Background Binge drinking (BD) involves consuming large amounts of alcohol within a short
timeframe, leading to a blood alcohol concentration of 0.08 g/dL or above. This pattern of …

[PDF][PDF] Cortisol modulates salient alcohol encoding and promotes later alcohol motivation

BB Harris, R Sinha, EV Goldfarb - PsyArXiv. doi, 2024 - osf.io
Glucocorticoids, a key part of the body's response to both stress and appetitive substances,
can strongly influence the formation of memory for emotional experiences. However, the …

Reply to Bradford: Comment on increasing ecological validity in neuropsychopharmacology research on the relationship between alcohol use and uncertain stressors

M Radoman, SM Gorka - Neuropsychopharmacology, 2024 - nature.com
In their commentary, Bradford and colleagues [1] discuss the theory that exaggerated
reactivity to uncertain threat (U-threat) contributes to the onset and maintenance of …