Asynchrony between virus diversity and antibody selection limits influenza virus evolution

DH Morris, VN Petrova, FW Rossine, E Parker… - Elife, 2020 - elifesciences.org
Seasonal influenza viruses create a persistent global disease burden by evolving to escape
immunity induced by prior infections and vaccinations. New antigenic variants have a …

Porcine respiratory coronavirus as a model for acute respiratory coronavirus disease

S Keep, BV Carr, FZX Lean, A Fones… - Frontiers in …, 2022 - frontiersin.org
In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic,
we have developed a porcine respiratory coronavirus (PRCV) model for in depth …

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred babraham pigs and outbred pigs

M Edmans, A McNee, E Porter, E Vatzia… - Frontiers in …, 2021 - frontiersin.org
We have used the pig, a large natural host animal for influenza with many physiological
similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to …

[HTML][HTML] Influenza A Viruses in the Swine Population: Ecology and Geographical Distribution

N Klivleyeva, N Saktaganov, T Glebova, G Lukmanova… - Viruses, 2024 - mdpi.com
Despite the efforts of practical medicine and virology, influenza viruses remain the most
important pathogens affecting human and animal health. Swine are exposed to infection …

Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs

V Martini, M Hinchcliffe, E Blackshaw, M Joyce… - Frontiers in …, 2020 - frontiersin.org
Recent evidence indicates that local immune responses and tissue resident memory T cells
(TRM) are critical for protection against respiratory infections but there is little information on …

Risk assessment of influenza transmission between workers and pigs on US indoor hog growing units

E Kontowicz, M Moreno-Madriñan, Z Clarke… - Preventive Veterinary …, 2024 - Elsevier
On pig farms ample opportunity exists for pig-to-human and human-to-pig (cross-species)
influenza transmission. The purpose of this study was to assess the risks of cross-species …

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B Holzer, P Rijal, A McNee, B Paudyal, V Martini… - PLoS …, 2021 - journals.plos.org
Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally
involved in virus evolution with frequent interspecies transmissions in both directions. The …

Vaccines that reduce viral shedding do not prevent transmission of H1N1 pandemic 2009 swine influenza a virus infection to unvaccinated pigs

HE Everett, PM van Diemen, M Aramouni… - Journal of …, 2021 - Am Soc Microbiol
Swine influenza A virus (swIAV) infection causes substantial economic loss and disease
burden in humans and animals. The 2009 pandemic H1N1 (pH1N1) influenza A virus is now …

Immune Responses to Pandemic H1N1 Influenza Virus Infection in Pigs Vaccinated with a Conserved Hemagglutinin HA1 Peptide Adjuvanted with CAF®01 or CDA …

S López-Serrano, L Cordoba, M Pérez-Maillo… - Vaccines, 2021 - mdpi.com
This study aimed to evaluate the immune response and protection correlates against
influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate …

The WUR0000125 PRRS resilience SNP had no apparent effect on pigs' infectivity and susceptibility in a novel transmission trial

M Chase-Topping, G Plastow, J Dekkers, Y Li… - Genetics Selection …, 2023 - Springer
Background Porcine reproductive and respiratory syndrome (PRRS) remains one of the
most important infectious diseases for the pig industry. A novel small-scale transmission …