The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

Several mechanisms underlying tumor progression have remained elusive, particularly in
relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial …

The metastatic process in breast cancer is related to the expression of the epithelial-to-
mesenchymal transition transcription factors (EMT-TFs) SNAIL, SLUG, SIP1 and TWIST1 …

Vimentin is used widely as a marker of the epithelial to mesenchymal transitions (EMTs) that
take place during embryogenesis and metastasis, yet the functional implications of the …

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

Leukocyte infiltration plays an active role in controlling tumor development. In the early
stages of carcinogenesis, T cells counteract tumor growth. However, in advanced stages …

Prostate cancer is a main urological disease associated with significant morbidity and
mortality. Radical prostatectomy and radiotherapy are potentially curative for localized …

The epithelial–mesenchymal transition (EMT) has been postulated as a mechanism by
which cancer cells acquire the invasive and stem-like traits necessary for distant metastasis …

Prostate cancer (PC) progressed to castration resistance (CRPC) is a fatal disease. CRPC
tumors develop resistance to new-generation antiandrogen enzalutamide through lineage …