The Warburg effect: a signature of mitochondrial overload
A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …
Metabolism of dietary and microbial vitamin B family in the regulation of host immunity
K Yoshii, K Hosomi, K Sawane, J Kunisawa - Frontiers in nutrition, 2019 - frontiersin.org
Vitamins are micronutrients that have physiological effects on various biological responses,
including host immunity. Therefore, vitamin deficiency leads to increased risk of developing …
including host immunity. Therefore, vitamin deficiency leads to increased risk of developing …
[HTML][HTML] Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
CBN Lauson, S Tiberti, PA Corsetto, F Conte, P Tyagi… - Cell Metabolism, 2023 - cell.com
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
Understanding the mechanisms underlying how T cells become dysfunctional in a tumor
microenvironment (TME) will greatly benefit cancer immunotherapy. We found that …
microenvironment (TME) will greatly benefit cancer immunotherapy. We found that …
Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation
Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …
[HTML][HTML] An activity-guided map of electrophile-cysteine interactions in primary human T cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …
on immune cells. These compounds are thought to act by cysteine modification to alter the …
T cell metabolism in infection
JA Wik, BS Skålhegg - Frontiers in immunology, 2022 - frontiersin.org
T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
N Lopes, C McIntyre, S Martin, M Raverdeau… - Nature …, 2021 - nature.com
Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …
T cell responses to the microbiota
II Ivanov, T Tuganbaev, AN Skelly… - Annual review of …, 2022 - annualreviews.org
The immune system employs recognition tools to communicate with its microbial
evolutionary partner. Among all the methods of microbial perception, T cells enable the …
evolutionary partner. Among all the methods of microbial perception, T cells enable the …
Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation
T cell subsets including effector (T eff), regulatory (T reg), and memory (T mem) cells are
characterized by distinct metabolic profiles that influence their differentiation and function …
characterized by distinct metabolic profiles that influence their differentiation and function …