Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

Recent studies have implicated chemokines in microglial activation and pathogenesis of
neuropathic pain. CXC motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Abstract Background Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been
implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic …

Neuropathic pain remains a pressing clinical problem. Here, we demonstrate that a local,
intrathecal (it) injection of bone marrow stromal cells (BMSCs) following lumbar puncture …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

One of the more important recent advances in neuroscience research is the understanding
that there is extensive communication between the immune system and the central nervous …

Chemokines and chemokine receptors are widely expressed by cells of the immune and
nervous systems. This review focuses on our current knowledge concerning the role of …