Proteases play critical roles in virtually all biological processes, including proliferation, cell
death and survival, protein turnover, and migration. However, when dysregulated, these …

The majority of breast cancer patients is treated with breast-conserving surgery (BCS)
combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive …

Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer with poor
prognosis. In the present study, we demonstrated that Src, a non-receptor tyrosine kinase …

While human in vitro embryo production is generally performed individually, animal models
have shown that culturing embryos in groups improves blastocyst yield and quality …

Cysteine cathepsins (CTS), being involved in both physiological and pathological
processes, play an important role in the human body. During the last 30 years, it has been …

While research into the role of cathepsins has been progressing at an exponential pace over
the years, research into their respective isoform proteins has been less frenetic. In view of …

This study was directed to assess the clinical impact of the circulating cathepsin L, cystatin
C, activin A, and follistatin in breast cancer patients. The serum concentrations of these …

Breast cancer metastasis is associated with a poor prognosis and a high rate of mortality.
Cathepsin L (CTSL) is a lysosomal cysteine protease that promotes tumor metastasis by …

Abstract Introduction Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's
proteases, which plays a key role in the virus's entry into the cell and subsequent infection …

The recent developments in Cathepsin protease research have unveiled a number of key
observations which are fundamental to further our understanding of normal cellular …