Pathways underlying mouse embryonic development have always informed efforts to derive,
maintain, and drive differentiation of human pluripotent stem cells. However, direct …

CRISPR and CRISPR-associated (Cas) protein, as components of microbial adaptive
immune system, allows biologists to edit genomic DNA in a precise and specific way …

Abstract Facioscapulohumeral dystrophy (FSHD; MIM 158900, MIM 158901) is caused by
misexpression of the DUX4 transcription factor in skeletal muscle. Animal models of FSHD …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that
retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is …

DNA methylation at the C-5 position of cytosine (5mC) is one of the best-studied epigenetic
modifications and plays important roles in diverse biological processes. Iterative oxidation of …

Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate
a full organism, including extra-embryonic tissues. A rare population of cells resembling 2 …

Minority subpopulations within embryonic stem cell cultures display an expanded
developmental potential similar to that of early embryo blastomeres or the early inner cell …

Endogenous retroviruses (ERVs) contribute to∼ 10 percent of the mouse genome. They are
often silenced in differentiated somatic cells but differentially expressed at various …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …