Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …

Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal
development, survival, and function in the central nervous system (CNS), being implicated in …

Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD
pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical …

Distal axon degeneration seen in many peripheral neuropathies is likely to share common
molecular mechanisms with Wallerian degeneration. Although several studies in mouse …