Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …

Diverse inflammatory diseases, infections and malignancies are associated with wasting
syndromes. In many of these conditions, the standards for diagnosis and treatment are …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Abstract Growth differentiation factor 15 (GDF15), a distant member of the transforming
growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In …

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with
poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral …

Abstract Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent
member of the TGF-β superfamily and is associated with body-weight regulation in humans …

GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific
hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …