Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Eosinophilic esophagitis (EE) is an emerging disorder with a poorly understood
pathogenesis. In order to define disease mechanisms, we took an empirical approach …

Thymic stromal lymphopoietin (TSLP) is elevated in asthma and triggers dendritic cell-
mediated activation of Th2 inflammatory responses. Although TSLP has been shown to be …

In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the
eosinophil, by placing it in the context of innate and adaptive immune responses …

Chemokines are a family of proteins associated with the trafficking of leukocytes in
physiological immune surveillance and inflammatory cell recruitment in host defence. They …

Background: IL-13 induces several characteristic features of asthma, including airway
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the …

The asthmatic response is characterized by elevated production of IgE, cytokines,
chemokines, mucus hypersecretion, airway obstruction, eosinophilia, and enhanced airway …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

Background Diffuse macular edema (DME) and/or aberrant neovascularization (NV) can
cause vision loss in diabetic retinopathy (DR) and may be modulated bygrowth factors and …