Molecular mechanisms of inner ear development
DK Wu, MW Kelley - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …
The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding
RL Ochs, M Mahler, A Basu, L Rios-Colon… - Clinical and …, 2016 - Springer
Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy
Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …
Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease
T Requena, S Cabrera, C Martín-Sierra… - Human molecular …, 2015 - academic.oup.com
Meniere's disease (MD) is a chronic disorder of the inner ear defined by sensorineural
hearing loss, tinnitus and episodic vertigo, and familial MD is observed in 5–15% of sporadic …
hearing loss, tinnitus and episodic vertigo, and familial MD is observed in 5–15% of sporadic …
MiRNA-21: a biomarker predictive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer
W Gao, X Lu, L Liu, J Xu, D Feng… - Cancer biology & therapy, 2012 - Taylor & Francis
Purpose: To investigate the possible role of microRNAs in the resistance to platinum based
chemotherapy in non-small cell lung cancer (NSCLC), explore their potential role and find …
chemotherapy in non-small cell lung cancer (NSCLC), explore their potential role and find …
Genetics of allergic diseases
RA Ortiz, KC Barnes - Immunology and allergy clinics of North …, 2014 - pmc.ncbi.nlm.nih.gov
The allergic diseases are complex phenotypes for which a strong genetic basis has been
firmly established. Genome-wide association studies (GWAS) has been widely employed in …
firmly established. Genome-wide association studies (GWAS) has been widely employed in …
Joint analysis of miRNA and mRNA expression data
A Muniategui, J Pey, FJ Planes… - Briefings in …, 2013 - academic.oup.com
Abstract miRNAs are small RNA molecules (′ 22 nt) that interact with their target mRNAs
inhibiting translation or/and cleavaging the target mRNA. This interaction is guided by …
inhibiting translation or/and cleavaging the target mRNA. This interaction is guided by …
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris
BA Wilkerson, HL Zebroski, CR Finkbeiner… - Elife, 2021 - elifesciences.org
This study provides transcriptomic characterization of the cells of the crista ampullaris,
sensory structures at the base of the semicircular canals that are critical for vestibular …
sensory structures at the base of the semicircular canals that are critical for vestibular …
Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate
SH Kim, JY Kim, HJ Lee, M Gi, BG Kim, JY Choi - PloS one, 2014 - journals.plos.org
Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo,
sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism …
sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism …
Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate
Background To study the role of microRNA (miRNA) in the regulation of Chinese hamster
ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were …
ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were …