Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Abstract Mangosteen (Garcinia mangostana L.), also known as the “queen of fruits”, is a
tropical fruit of the Clusiacea family. While native to Southeast Asian countries, such as …

Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …

Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is
one of the main active ingredients of the hull of the mangosteen. The main objective of the …

Abstract Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various
biological processes and is deemed as a novel biomarker for different cancers. Depending …

Sirtuins are NAD+-dependent deac (et) ylases with different subcellular localization. The
sirtuins' family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates …

Diabetes is a chronic metabolic disorder characterized by raised glucose levels in the blood,
resulting in grave damage over time to various body organs, including the nerves, heart …

α-Mangostin is a xanthone natural product isolated as a secondary metabolite from the
mangosteen tree. It has attracted a great deal of attention due to its wide-ranging effects on …

Epigenetics mainly refers to covalent modifications to DNA or histones without affecting
genomes, which ultimately lead to phenotypic changes in cells or organisms. Given the …