The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased
oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been …

Functional analyses of genes linked to heritable forms of Parkinson's disease (PD) have
revealed fundamental insights into the biological processes underpinning pathogenic …

Subarachnoid hemorrhage (SAH) is a type of stroke with a high disability and mortality rate.
Apoptosis caused by massive damage to mitochondria in neuron cells and inflammatory …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder among the elderly
population. The pathogenesis of PD encompasses genetic alterations, environmental …

Parkinson's disease (PD) is the second most common neurodegenerative disease with
currently no cure. Most PD cases are sporadic, and about 5–10% of PD cases present a …

Mutations in FBXO7 have been discovered to be associated with an atypical parkinsonism.
We report here a new homozygous missense mutation in a paediatric patient that causes an …

Lysosomal storage diseases (LSDs) comprised~ 50 monogenic diseases characterized by
the accumulation of cellular material in lysosomes and associated defects in lysosomal …

Parkinson's disease is a common neurodegenerative disease with movement disorders
associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in …