Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative
phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) …

Background The initiation and regulation of pulmonary fibrosis are not well understood. IL-
33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients …

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease and is
presumed to be central to the altered responsiveness to recurrent infection in these patients …

Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …

The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …

Abstract Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial
and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra-and …