Extracellular vesicles in obesity and diabetes mellitus

F Pardo, R Villalobos-Labra, B Sobrevia… - Molecular aspects of …, 2018 - Elsevier
Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes

N Jayabalan, S Nair, Z Nuzhat, GE Rice… - Frontiers in …, 2017 - frontiersin.org
Obesity is an important public health issue worldwide, where it is commonly associated with
the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity …

Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis

C Salomon, J Ryan, L Sobrevia, M Kobayashi… - PloS one, 2013 - journals.plos.org
Vasculogenesis and angiogenesis are critical processes in fetal circulation and placental
vasculature development. Placental mesenchymal stem cells (pMSC) are known to release …

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

S Finer, C Mathews, R Lowe, M Smart… - Human molecular …, 2015 - academic.oup.com
Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown to
programme future risk of diabetes and obesity. Epigenetic variation in foetal tissue may have …

Who is who in adenosine transport

M Pastor-Anglada, S Pérez-Torras - Frontiers in pharmacology, 2018 - frontiersin.org
Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Epigenetic programming, early life nutrition and the risk of metabolic disease

T Block, A El-Osta - Atherosclerosis, 2017 - Elsevier
Time separates the past from the present, during this period memory are formed-written in
code and decoded to be read while other memories are erased-but when it comes to the …

Gestational diabesity and foetoplacental vascular dysfunction

M Cornejo, G Fuentes, P Valero, S Vega… - Acta …, 2021 - Wiley Online Library
Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D‐glucose and
other nutrients, thereby negatively affecting the foetoplacental vascular endothelium …

Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus

P Valero, G Fuentes, M Cornejo, S Vega… - Molecular Aspects of …, 2022 - Elsevier
A balanced communication between the mother, placenta and foetus is crucial to reach a
successful pregnancy. Several windows of exposure to environmental toxins are present …

Transporter regulation in critical protective barriers: focus on brain and placenta

V Taggi, M Riera Romo, M Piquette-Miller… - Pharmaceutics, 2022 - mdpi.com
Drug transporters play an important role in the maintenance of chemical balance and
homeostasis in different tissues. In addition to their physiological functions, they are crucial …

Endothelial dysfunction in pregnancy complications

J Kornacki, P Gutaj, A Kalantarova, R Sibiak… - Biomedicines, 2021 - mdpi.com
The endothelium, which constitutes the inner layer of blood vessels and lymphatic
structures, plays an important role in various physiological functions. Alterations in structure …