Overcoming anti-PD-1/PD-L1 immune checkpoint blockade resistance: the role of macrophage, neutrophils and mast cells in the tumor microenvironment
LB Kwantwi - Clinical and Experimental Medicine, 2023 - Springer
In recent years, the anti-PD-1/PD-L1 blockade has become a game changer in cancer
treatment following the unprecedented response rate. Regardless of the substantial therapy …
treatment following the unprecedented response rate. Regardless of the substantial therapy …
[HTML][HTML] NFAT signaling dysregulation in cancer: emerging roles in cancer stem cells
Y Lin, Y Song, Y Zhang, M Shi, A Hou, S Han - Biomedicine & …, 2023 - Elsevier
The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional
regulator of activated T cells. The NFAT family is involved in the development of tumors …
regulator of activated T cells. The NFAT family is involved in the development of tumors …
Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration
Y Xie, S Tolmeijer, JM Oskam… - Disease models & …, 2019 - journals.biologists.com
Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is
limited by side effects and by resistance, which especially occurs in macrophage-dominated …
limited by side effects and by resistance, which especially occurs in macrophage-dominated …
Triple-negative breast cancer cells recruit neutrophils by secreting TGF-β and CXCR2 ligands
S SenGupta, LE Hein, Y Xu, J Zhang… - Frontiers in …, 2021 - frontiersin.org
Tumor associated neutrophils (TANs) are frequently detected in triple-negative breast
cancer (TNBC). Recent studies also reveal the importance of neutrophils in promoting tumor …
cancer (TNBC). Recent studies also reveal the importance of neutrophils in promoting tumor …
The RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer
L Ge, Y Rui, C Wang, Y Wu, H Wang, J Wang - Cell Death & Disease, 2024 - nature.com
Abstract N 6-methyladenosine (m6A) and its associated reader protein insulin like growth
factor 2 mRNA binding protein 3 (IGF2BP3) are involved in tumor initiation and progression …
factor 2 mRNA binding protein 3 (IGF2BP3) are involved in tumor initiation and progression …
Diamonds in the rough: harnessing tumor-associated myeloid cells for cancer therapy
EJ Clappaert, A Murgaski, H Van Damme… - Frontiers in …, 2018 - frontiersin.org
Therapeutic approaches that engage immune cells to treat cancer are becoming
increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid …
increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid …
SKAP1 expression in cancer cells enhances colon tumor growth and impairs cytotoxic immunity by promoting Neutrophil Extracellular trap formation via the NFATc1 …
J Gao, J Liu, J Lu, X Zhang, W Zhang, Q Li… - Advanced …, 2024 - Wiley Online Library
The mechanisms underlying the development and progression of colon cancer are not fully
understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell …
understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell …
Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus …
X Wang, C Zhao, C Zhang, X Mei, J Song… - Cell Communication and …, 2019 - Springer
Background Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1)
mRNA expression is observed in systemic lupus erythematosus (SLE) patients and …
mRNA expression is observed in systemic lupus erythematosus (SLE) patients and …
Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma
S Sánchez‐Ovando, JL Simpson… - Clinical & …, 2021 - Wiley Online Library
Background Severe asthma is a complex disease. Transcriptomic profiling has contributed
to understanding the pathogenesis of asthma, especially type‐2 inflammation. However …
to understanding the pathogenesis of asthma, especially type‐2 inflammation. However …
Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer …
Y Miao, Q Shen, S Zhang, H Huang, X Meng… - Breast Cancer …, 2019 - Springer
Background Stromal interaction molecule (STIM) 2 is a key calcium-sensing molecule that
regulates the stabilization of calcium ions (Ca 2+) and therefore regulates downstream Ca …
regulates the stabilization of calcium ions (Ca 2+) and therefore regulates downstream Ca …