High throughput screening technologies for ion channels

H Yu, M Li, W Wang, X Wang - Acta Pharmacologica Sinica, 2016 - nature.com
Ion channels are involved in a variety of fundamental physiological processes, and their
malfunction causes numerous human diseases. Therefore, ion channels represent a class of …

Genetic neurological channelopathies: molecular genetics and clinical phenotypes

J Spillane, DM Kullmann, MG Hanna - Journal of Neurology …, 2016 - jnnp.bmj.com
Evidence accumulated over recent years has shown that genetic neurological
channelopathies can cause many different neurological diseases. Presentations relating to …

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

Y Yang, Y Wang, S Li, Z Xu, H Li, L Ma, J Fan… - Journal of medical …, 2004 - jmg.bmj.com
Primary erythermalgia is a rare autosomal dominant disease characterised by intermittent
burning pain with redness and heat in the extremities. A previous study established the …

[图书][B] Seafood and freshwater toxins: pharmacology, physiology, and detection

LM Botana - 2014 - books.google.com
The last few years have brought about many changes in the field of marine and freshwater
toxins, with advances in analytical technology and the realization that these toxins are a …

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

ST Hansen, P Meera, TS Otis… - Human molecular …, 2013 - academic.oup.com
Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the …

Xenbase: Facilitating the Use of Xenopus to Model Human Disease

MJ Nenni, ME Fisher, C James-Zorn, TJ Pells… - Frontiers in …, 2019 - frontiersin.org
At a fundamental level most genes, signaling pathways, biological functions and organ
systems are highly conserved between man and all vertebrate species. Leveraging this …

The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

SS Sanders, LM Hernandez, H Soh, S Karnam… - Elife, 2020 - elifesciences.org
The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and
is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However …

Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels

AL Firth, CV Remillard, O Platoshyn… - Pulmonary …, 2011 - journals.sagepub.com
The activity of voltage-gated ion channels is critical for the maintenance of cellular
membrane potential and generation of action potentials. In turn, membrane potential …

[HTML][HTML] Integrated K+ channel and K+ Cl-cotransporter functions are required for the coordination of size and proportion during development

JS Lanni, D Peal, L Ekstrom, H Chen, C Stanclift… - Developmental …, 2019 - Elsevier
The coordination of growth during development establishes proportionality within and
among the different anatomic structures of organisms. Innate memory of this proportionality …

[HTML][HTML] Informatic challenges and advances in illuminating the druggable proteome

R Taujale, N Gravel, Z Zhou, W Yeung, K Kochut… - Drug discovery today, 2024 - Elsevier
Highlights•Prediction of understudied protein kinase and pseudokinase functions using
evolutionary inference.•Integration and mining of heterogeneous data sources for drug …