Ion channels are involved in a variety of fundamental physiological processes, and their
malfunction causes numerous human diseases. Therefore, ion channels represent a class of …

Evidence accumulated over recent years has shown that genetic neurological
channelopathies can cause many different neurological diseases. Presentations relating to …

Primary erythermalgia is a rare autosomal dominant disease characterised by intermittent
burning pain with redness and heat in the extremities. A previous study established the …

The last few years have brought about many changes in the field of marine and freshwater
toxins, with advances in analytical technology and the realization that these toxins are a …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the …

At a fundamental level most genes, signaling pathways, biological functions and organ
systems are highly conserved between man and all vertebrate species. Leveraging this …

The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and
is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However …

The activity of voltage-gated ion channels is critical for the maintenance of cellular
membrane potential and generation of action potentials. In turn, membrane potential …

The coordination of growth during development establishes proportionality within and
among the different anatomic structures of organisms. Innate memory of this proportionality …

Highlights•Prediction of understudied protein kinase and pseudokinase functions using
evolutionary inference.•Integration and mining of heterogeneous data sources for drug …